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Histopathology

Histopathology

The STTARR's histopathology core now provides 100+ optimized antibodies for immunohistochemistry/immunofluorescence. The histopathology core now specializes in the special MOVAT stain (highlights the various constituents of connective tissue, especially cardiovascular tissue, by five colors in a single stained slide). The new development of an in-situ hybridization protocol combined with immunofluorescence or human X-Y chromosome assays is now a histopathology service offered at STTARR.

Hematoxylin and eosin staining on a lung tissue

Image of Hematoxylin and eosin staining on a lung tissue

Kidney tubules marker stained by IF

Image of kidney tubules marker stained by IF

CA9 IHC for hypoxia screening

Image of CA9 IHC for hypoxia screening

Movat pentachrome

Image of Movat pentachrome

Services include:

▸ Formalin fixed Paraffin embedded (FFPE) tissue services
  • Grossing

    Inspect the samples for fixation statues, trimming harvest tissue to the plain of interest.

  • Tissue processing & embedding (regular and wholemount)

    Regular cassettes size is 30mm x 35mm.
    Supersize cassette for wholemount is 65mmX50mm.

  • Re-embedding

    Melt down paraffin block and re-orient the tissue into the desire cutting plain.

▸ Frozen tissue services
  • Cryo block sectioning

    Sectioning OCT frozen tissue blocks prepared by users.

  • Regular tissue specimen Freezing

    User provide fresh harvested tissue to STTARR Histopathology for snap freezing in OCT.

  • Muscle Specimen Freezing

    Special snap freezing technique for muscle tissue prone to freeze artifact.

▸ Microtomy
  • Microtomy

    Sectioning paraffin and frozen section at routine 4um thickness or in special thickness requested by user.

  • Paraffin Microtomy

    Regular slides: 25mmx75mm.
    Wholemount large slide:50mmx75mm.

  • Serial sections

    Paraffin or frozen (per slide) consecutive sections from a ribbon of section mounted on slides labelled with numbers.

  • Specific micro-structure/Precise sectioning

    Look for specific microscopic structures in paraffin/frozen blocks and take sections eg. Mouse aortic arch, aortic root, mouse embryo thyroid glands.

▸ Immunohistochemistry
  • IHC New Antibody Optimization

    Optimization of commercial and/or in house produced antibodies.

  • Immunohistochemistry

    Check out our Histopathology Optimized Antibody List for a list of antibodies currently available and optimized at STTARR Histopathology. Please note that the list is continuously updated. If the antibody you are interested in is not on the list, please contact us.

  • New service

    We also offer validated antibodies for immunohistochemistry staining on porcine tissue.

  • Multiplex IF staining

    Multiplex of up to 3 target proteins in cells/tissues using fluorescent tagged antibodies.

  • Tunel assay

    Detection of DNA fragmentation in last phase of apoptosis (cell death).

▸ In situ hybridization
  • In Situ Hybridization (RNAscope)

    Uitlizing ACDBio System probes and detection systems to detect target mRNA in paraffin embedded sections.

▸ Special Stains
  • Special Stains & Enzyme Histochemistry

    Masson trichrome, Elastic Trichrome, Picrosirius red,Periodic acid Schiff, Cresyl echt violet, Luxol fast blue, Gram stain, von Kossa calcium, Oil O red, Gordon & Sweets Siliver Reticular fiberstain, Safranin O, MOVAT, Prussian blue, Fontana Masson and fast green, TRAP(Tartaric Acid Resistant Phosphotase).
    STTARR Histopathology has other histochemistry stain protocols that are available upon request, please inquire if the stain that you are interested is not on the list.

▸ H&E staining

Principle and routine stain used in histopathology perform on paraffin or frozen sections.

▸ Other services
  • Autoradiography

    Sectioning thick sections (3--50microns) for autoradiography, 2 sets of slides each sample. Protocol on sample preparation for autoradiography available upon request.

  • Cell pellet agar embedding

    Centrifuge cell pellet and double embed into agar gel and paraffin.

  • Decalcification - acid

    Formic acid for rapid decalcification or EDTA for tissue to be used for IHC.

  • Full necropsy (mouse, rat, guinea pig)

    Havest tissue for toxicology study or specific organ of interest.

  • Tissue microarray construction

    Combining multiple donor tissue parrafin blocks into one for high throughput IHC staining.

Services

STTARR offers services and facilities needed for translational drug development and preclinical research.
Our services include:
Icon image of cell

Histopathology

The STTARR's histopathology core now provides 100+ optimized antibodies for immunohistochemistry/immunofluorescence. The histopathology core now specializes in the special MOVAT stain (highlights the various constituents of connective tissue, especially cardiovascular tissue, by five colors in a single stained slide). The new development of an in-situ hybridization protocol combined with immunofluorescence or human X-Y chromosome assays is now a histopathology service offered at STTARR.

Services include:

▸ Formalin fixed Paraffin embedded (FFPE) tissue services
  • Grossing

    Inspect the samples for fixation statues, trimming harvest tissue to the plain of interest.

  • Tissue processing & embedding (regular and wholemount)

    Regular cassettes size is 30mm x 35mm.
    Supersize cassette for wholemount is 65mmX50mm.

  • Re-embedding

    Melt down paraffin block and re-orient the tissue into the desire cutting plain.

▸ Frozen tissue services
  • Cryo block sectioning

    Sectioning OCT frozen tissue blocks prepared by users.

  • Regular tissue specimen Freezing

    User provide fresh harvested tissue to STTARR Histopathology for snap freezing in OCT.

  • Muscle Specimen Freezing

    Special snap freezing technique for muscle tissue prone to freeze artifact.

▸ Microtomy
  • Microtomy

    Sectioning paraffin and frozen section at routine 4um thickness or in special thickness requested by user.

  • Paraffin Microtomy

    Regular slides: 25mmx75mm.
    Wholemount large slide:50mmx75mm.

  • Serial sections

    Paraffin or frozen (per slide) consecutive sections from a ribbon of section mounted on slides labelled with numbers.

  • Specific micro-structure/Precise sectioning

    Look for specific microscopic structures in paraffin/frozen blocks and take sections eg. Mouse aortic arch, aortic root, mouse embryo thyroid glands.

▸ Immunohistochemistry
  • IHC New Antibody Optimization

    Optimization of commercial and/or in house produced antibodies.

  • Immunohistochemistry

    Check out our Histopathology Optimized Antibody List for a list of antibodies currently available and optimized at STTARR Histopathology. Please note that the list is continuously updated. If the antibody you are interested in is not on the list, please contact us.

  • New service

    We also offer validated antibodies for immunohistochemistry staining on porcine tissue.

  • Multiplex IF staining

    Multiplex of up to 3 target proteins in cells/tissues using fluorescent tagged antibodies.

  • Tunel assay

    Detection of DNA fragmentation in last phase of apoptosis (cell death).

▸ In situ hybridization
  • In Situ Hybridization (RNAscope)

    Uitlizing ACDBio System probes and detection systems to detect target mRNA in paraffin embedded sections.

▸ Special Stains
  • Special Stains & Enzyme Histochemistry

    Masson trichrome, Elastic Trichrome, Picrosirius red,Periodic acid Schiff, Cresyl echt violet, Luxol fast blue, Gram stain, von Kossa calcium, Oil O red, Gordon & Sweets Siliver Reticular fiberstain, Safranin O, MOVAT, Prussian blue, Fontana Masson and fast green, TRAP(Tartaric Acid Resistant Phosphotase).
    STTARR Histopathology has other histochemistry stain protocols that are available upon request, please inquire if the stain that you are interested is not on the list.

▸ H&E staining

Principle and routine stain used in histopathology perform on paraffin or frozen sections.

▸ Other services
  • Autoradiography

    Sectioning thick sections (3--50microns) for autoradiography, 2 sets of slides each sample. Protocol on sample preparation for autoradiography available upon request.

  • Cell pellet agar embedding

    Centrifuge cell pellet and double embed into agar gel and paraffin.

  • Decalcification - acid

    Formic acid for rapid decalcification or EDTA for tissue to be used for IHC.

  • Full necropsy (mouse, rat, guinea pig)

    Havest tissue for toxicology study or specific organ of interest.

  • Tissue microarray construction

    Combining multiple donor tissue parrafin blocks into one for high throughput IHC staining.

Icon image of a human sitting in front of a computer

Consulting & Education

Scientific consulting & project management, workshops, user training and facility tours available

  • Our scientists provide comprehensive support throughout study conception, project management, method development, and data analysis
  • We offer workshops on molecular imaging, user training sessions and facility tours. Please contact us for personalized workshop and training opportunities

For more information on Internal and External rates, please contact us or Naz Chaudary.

Team